Low-carbon hydrogen can assist in addressing the global crisis of climate change by significantly decarbonizing a range of heavy-emitting sectors. In the United Kingdom, hydrogen technologies are at the forefront of the net zero-emission roadmaps of many industrial clusters. However, with impending timeframes linked to emission targets and other decarbonization objectives, it is increasingly important to understand how to accelerate such transitions to hydrogen. There is, to date, a notable gap in the academic literature concerning the acceleration of sustainability transitions. Using the case of the hydrogen agenda in England’s North West region, we explore how the transition to hydrogen can be accelerated and thus begin to contribute toward filling this omission. In doing so, we use data collected through semi-structured interviews and from the public domain to unpack and develop upon an existing framework that emerged from the European Commission funded-project Accelerating and Rescaling Transitions to Sustainability (ARTS). The framework comprises five acceleration mechanisms which local sustainability transition initiatives have adopted. This analysis generates novel findings in relation to why actors in the region have faced difficulties in instrumentalizing as well as the mechanism’s overall importance in acceleration. We use these challenges to inform several recommendations which policy makers could adopt to accelerate the North West’s, and wider UK’s, transition to hydrogen.