Abstract Environmental concerns are forcing the replacement of the commonly used refrigerants and finding new fluids is a top priority. The hydro-fluoro-olefin (HFO) R1234ze(E), because of its smaller global warming potential (GWP) and shorter atmospheric lifetime, replaced R134a. Accordingly, for HVAC systems design, a detailed knowledge of the thermo-fluid-dynamic characteristics of the fluids and reliable predictive models are required. To improve the understanding, R134a and R1234ze(E) were employed in convective condensation experiments (saturation temperature Tsat = 35°C, mean quality xm = 0.1~0.9, quality changes Δx = 0.05~0.6, mass flux G = 43~444 kg·m−2s−1) inside a microfin tube (outer diameter D = 9.52 mm, fin number n = 60, fin height H = 0.2 mm). The results were used for two goals: the former is the comparison of the heat transfer features of the two fluids, while the latter aims at testing the performance of prediction models available in the open literature. At the saturation temperature T = 35°C, the two fluids show small differences in the thermal properties so that, as expected, the experiments highlighted a very similar behavior in the typical operating conditions of HVAC systems. In fact, for all the operating conditions marginal differences were observed in the pressure drop, the heat transfer coefficient and the flow pattern maps. The issue of prediction reliability, however, is still open. Actually, not all the models achieving good results for R134a show the same performance for R1234ze(E), especially for the pressure drop.