Abstract The buildings and construction sector is responsible for nearly 40% of the total greenhouse emissions (GHG). Considering 50% of the building stock that will exist in 2050 is yet to be built and most of it will be devoted to housing; the sector is a determinant and transformative force to strengthen sustainability, reducing CO2 emissions and environmental degradation worldwide. Most of the increase in construction and housing is set to occur in developing countries and mainly in cities in Asia and Africa. This global picture places new housing programs in the rapidly urbanising regions as potential agents of sustainable transformation, with positive outcomes for both communities and the environment. Investing in sustainable housing has significant and real value in reducing emissions, confronting climate change, and generating better planned, inclusive, and sustainable cities. The holistic benefit achieved with the implementation of carbon neutral and carbon negative technologies is often scattered, and an integrated view of it would be a key tool to support the development of sustainable housing programmes. Considering that technologies to decarbonize and render the construction sector more sustainable have already been developed, there is a need to contrast their applicability to different countries and contexts in order to verify their functionality and identify gaps for improvement. The recent decade has witnessed a significant improvement at the global level with regards to the application of the concept of sustainability to the built environment, this being demonstrated by the multiple sustainability ratings and frameworks being developed to certify building performance. Their adoption has been critically important in most regions in the so-called Global North, where countries have started enforcing them at a normative level. While these tools’ accuracy and comprehensiveness could be disputed, their importance in promoting a systematic standardisation of the adoption of sustainability measures in the built environment is endorsed. Nevertheless, the diffusion of such tools and frameworks across rapidly urbanising middle and low-income countries has been so far extremely limited. There are myriad reasons why this is the case: tools based for high-income country contexts, their complexity, the need for accurate data and specific capacity for their adoption and diffusion, the lack of contextual relevance with regards to the specific market, culture and behavioural dynamics, and more. The following paper aims at demonstrating the value of shifting toward sustainable building practices by a comparative analysis of existing global tools and certifications and their applicability to low and middle-income countries undergoing a rapid urbanisation process. It proposes a three-phased multi-stakeholders methodology. The outcome of these three phases is combined, providing a more appropriate definition of effective and operative guidelines and tools for sustainable housing in rapidly urbanising middle and lowincome regions.