Current is no longer sinusoidal in modern electric networks because of widespread use of power electronic-based equipments and nonlinear loads. Usually AC loss is calculated for pure sinusoidal current, while it is no longer accurate when current is nonsinusoidal. On the other hand, efficiency of cooling system in large scale power devices is dependent on accurate estimation and prediction of the heat load caused by AC loss in design stage. Therefore, estimation of nonsinusoidal AC loss of high temperature superconducting (HTS) material would be of great interest for designers of large-scale superconducting devices. In this paper, at first nonsinusoidal AC loss of a typical HTS tape was calculated under distorted currents using H-formulation finite element method. Then, a range of artificial intelligence (AI) models were implemented to predict AC loss of a typical HTS tape. In order to find the best and more adaptive AI model for nonsinusoidal AC loss prediction, different regression models are evaluated using Support Vector Machine regression model, Generalized Linear regression model, Decision Tree regression model, Feed Forward Neural Network based model, Adaptive Neuro Fuzzy Inference System based model, and Radial Basis Function Neural Network (RBFNN) based model. In order to evaluate robustness of developed models cross-validation technique is implemented on experimental data. To compare the performance of different AI models, four prediction measures were used: Theil's U coefficients (UAccuracy and UQuality), Root Mean Square Error (RMSE) and Regression value (R-value). Obtained results show that best performance belongs to RBFNN based model and then ANFIS based model. U coefficients and RMSE values are obtained less than 0.005 and R-Value is become close to one by using RBFNN based model for testing data, which indicates high accuracy prediction performance.