In this paper, a multi-agent system based wide area protection scheme is proposed in order to prevent long term voltage instability induced cascading events. The distributed relays and controllers work as a device agent which not only executes the normal function automatically but also can be modified to fulfill the extra function according to external requirements. The control center is designed as a highest level agent in MAS to coordinate all the lower agents to prevent the system wide voltage disturbance. A hybrid simulation platform with MATLAB and RTDS is set up to demonstrate the effectiveness of proposed protection strategy. The simulation results indicate that the proposed multi agent control system can effectively coordinate the distributed relays and controllers to prevent the long term voltage instability induced cascading events.