In order to solve the problem of dynamic reconfiguration of distribution network connected with distributed generation (DG) and electric vehicle (EV), a dynamic reconfiguration method of distribution network based on time series symbolized segmentation is proposed. Firstly, the daily load curve of the distribution network accessed to distributed energy and electric vehicles is predicted. The time series of load is symbolized and the segmentation effect is evaluated by information entropy to determine the time division scheme. Then the model is established with the minimum daily operating loss cost as the objective function, and the distribution network is dynamically reconfigured according to the time division. The particle swarm optimization algorithm (PSO) based on branch group search is proposed to solve the model. Finally, the simulation calculation is carried out by using the IEEE33 node system as an example. The results show that the proposed method can reasonably divide the load time series, so that the daily opHrating loss cost of the distribution network after dynamic reconfiguration is reduced.