In order to fully tap the absorption potential of power grid regulation resources, including power sources, controllable load and energy storage, an optimal dispatch method based on source-network-load-storage interaction was proposed to realize the effective connection between power grid operation economy and new energy absorption. The operation characteristics of conventional power source, controllable load and energy storage is firstly studied including their operation cost and generation output regulation characteristics. Thus, the operation characteristic functions of the above regulating resources are constructed. Then, an optimal dispatch model considering source-network-load-storage interaction is proposed. The model aims to minimize the comprehensive power grid operation cost and the new energy power loss cost. And the power grid stable operation constraints and regulation resources operation constraints are also taken into consideration. Finally, a case study based on IEEE-30 buses system is constructed to verify the effectiveness of the proposed method.