This paper describes the implementation of Power hardware-in-the-loop (PHIL) infrastructure of the CoSES laboratory at TU Munich. We present a control system framework for PHIL test-beds with distributed real-time controllers, using NI Veristand environment. This framework combines real-time computation with software in charge of secondary and tertiary control. The arrangement works as a real-time control environment, with an API access for connection to computation tools and algorithms. Two experiments are presented to validate the PHIL performance and to demonstrate the use of proposed PHIL control framework in investigation of an Optimal Power Flow (OPF) algorithm.