This paper summarizes a modeling framework that characterizes the key underlying technologies and processes that contribute to the supply chain energy use and greenhouse gas (GHG) emissions of a variety of goods and services purchased by U.S. consumers. The framework couples an input-output supply chain modeling approach with “bottom-up” fuel end use models for individual IO sectors. This fuel end use modeling detail allows energy and policy analysts to better understand the underlying technologies and processes contributing to the supply chain energy and GHG “footprints” of goods and services. To illustrate the policy-relevance of this approach, a case study was conducted to estimate achievable household GHG footprint reductions associated with the adoption of best practice energy-efficient supply chain technologies.