This article proposed a new model for reconfiguration and distributed generation (DG) allocation in the distribution network by considering network loss reduction and power quality improvement. The objective function aims to minimize losses and improve power quality indices by using the new antlion optimizer (ALO) algorithm. The proposed reconfiguration has been investigated on an unbalanced IEEE 33-bus grid with and without DG resources and capacitors. In this study, a branch exchange technique with an optimization method is used to determine the best network arrangement. Simulation results are implemented in different scenarios. In each of the scenarios, power quality indices and network losses before and after the optimization are compared. The results indicate that by using the proposed method, the rate of power quality indices and the losses in the case study are reduced. Also, the results of this study were compared with the results of sample studies. The results show that ALO has better performance with the goal of power loss reduction.