Condition monitoring and diagnosis have become an essential part of power transformer asset management. A variety of online and offline measurements have been performed in utilities for evaluating different aspects of transformers' conditions. However, properly processing measurement data and explicitly correlating these data to transformer condition is not a trivial task. This paper proposes an intelligent framework for condition monitoring and assessment of power transformer. Within this framework, various signal processing and pattern recognition techniques are applied for automatically denoising sensor acquired signals, extracting representative characteristics from raw data, and identifying types of faults in transformers. This paper provides case studies to demonstrate the effectiveness of the proposed framework and techniques for power transformer asset management. The hardware and software platform for implementing the proposed intelligent framework will also be presented in this paper.