Prediction plays a vital role in the active distribution network voltage regulation under the high penetration of photovoltaics. Current prediction models aim at minimizing individual prediction errors but overlook their collective impacts on downstream decision-making. Hence, this paper proposes a safety-aware semi-end-to-end coordinated decision model to bridge the gap from the downstream voltage regulation to the upstream multiple prediction models in a coordinated differential way. The semi-end-to-end model maps the input features to the optimal var decisions via prediction, decision-making, and decision-evaluating layers. It leverages the neural network and the second-order cone program (SOCP) to formulate the stochastic PV/load predictions and the var decision-making/evaluating separately. Then the var decision quality is evaluated via the weighted sum of the power loss for economy and the voltage violation penalty for safety, denoted by regulation loss. Based on the regulation loss and prediction errors, this paper proposes the hybrid loss and hybrid stochastic gradient descent algorithm to back-propagate the gradients of the hybrid loss with respect to multiple predictions for enhancing decision quality. Case studies verify the effectiveness of the proposed model with lower power loss for economy and lower voltage violation rate for safety awareness.