The lack of CB1 receptors prevents neuroadapatations of both NMDA and GABAA receptors after chronic ethanol exposure
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Warnault, Vincent; Warnault, Vincent
Harvested from ORCID Public Data File
Houchi, Hakim; Houchi, Hakim
Derived by OpenAIRE algorithms or harvested from 3rd party repositories Barbier, Estelle; Barbier, Estelle
Derived by OpenAIRE algorithms or harvested from 3rd party repositories Pierrefiche, Olivier; Pierrefiche, Olivier
Harvested from ORCID Public Data File Vilpoux, Catherine; Vilpoux, Catherine
Harvested from ORCID Public Data File Ledent, Catherine; Ledent, Catherine
Derived by OpenAIRE algorithms or harvested from 3rd party repositories Warnault, Vincent; Warnault, Vincent
Harvested from ORCID Public Data File Houchi, Hakim; Houchi, Hakim
Derived by OpenAIRE algorithms or harvested from 3rd party repositories Barbier, Estelle; Barbier, Estelle
Derived by OpenAIRE algorithms or harvested from 3rd party repositories Pierrefiche, Olivier; Pierrefiche, Olivier
Harvested from ORCID Public Data File Vilpoux, Catherine; Vilpoux, Catherine
Harvested from ORCID Public Data File Ledent, Catherine; Ledent, Catherine
Derived by OpenAIRE algorithms or harvested from 3rd party repositories Naassila, Mickaël; Naassila, Mickaël
Harvested from ORCID Public Data FileThe lack of CB1 receptors prevents neuroadapatations of both NMDA and GABAA receptors after chronic ethanol exposure
AbstractAs the contribution of cannabinoid (CB1) receptors in the neuroadaptations following chronic alcohol exposure is unknown, we investigated the neuroadaptations induced by chronic alcohol exposure on both NMDA and GABAA receptors in CB1−/− mice. Our results show that basal levels of hippocampal [3H]MK‐801 ((1)‐5‐methyl‐10,11‐dihydro‐5Hdibenzo[a,d]cyclohepten‐5,10‐imine) binding sites were decreased in CB1−/− mice and that these mice were also less sensitive to the locomotor effects of MK‐801. Basal level of both hippocampal and cerebellar [3H]muscimol binding was lower and sensitivity to the hypothermic effects of diazepam and pentobarbital was increased in CB1−/− mice. GABAAα1, β2, and γ2 and NMDA receptor (NR) 1 and 2B subunit mRNA levels were altered in striatum of CB1−/− mice. Our results also showed that [3H]MK‐801 binding sites were increased in cerebral cortex and hippocampus after chronic ethanol ingestion only in wild‐type mice. Chronic ethanol ingestion did not modify the sensitivity to the locomotor effects of MK‐801 in both genotypes. Similarly, chronic ethanol ingestion reduced the number of [3H]muscimol binding sites in cerebral cortex, but not in cerebellum, only in CB1+/+ mice. We conclude that lifelong deletion of CB1 receptors impairs neuroadaptations of both NMDA and GABAA receptors after chronic ethanol exposure and that the endocannabinoid/CB1 receptor system is involved in alcohol dependence.
Male, CB1 -- genetics, Muscimol -- metabolism, MESH: Receptor, Cannabinoid, CB1, Mice, MESH: Animals, MESH: Receptors, GABA-A, MESH: Alcohol-Induced Disorders, Nervous System, Nervous System -- metabolism, Competitive -- drug effects, GABA-A -- drug effects, Muscimol, Brain, Sciences bio-médicales et agricoles, Protein Subunits -- genetics, MESH: Protein Subunits, Alcohol-Induced Disorders, Excitatory Amino Acid Antagonists -- pharmacology, MESH: Ethanol, Knockout, Physiological -- genetics, Binding, Competitive, Dose-Response Relationship, Alcohol-Induced Disorders, Nervous System, MESH: GABA Agonists, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], RNA, Messenger, Adaptation, MESH: Receptors, N-Methyl-D-Aspartate, Dose-Response Relationship, Drug, Ethanol, Animal, Brain Chemistry -- drug effects, Messenger -- metabolism, Protein Subunits, MESH: Binding Sites, MESH: Disease Models, Animal, Competitive -- physiology, MESH: Muscimol, MESH: Mice, Knockout, Binding Sites -- physiology, MESH: Dose-Response Relationship, Drug, Brain Chemistry -- genetics, Receptors, MESH: Brain Chemistry, GABA Agonists -- pharmacology, Mice, Knockout, Brain -- physiopathology, Alcoholism -- physiopathology, MESH: Excitatory Amino Acid Antagonists, Adaptation, Physiological, Ethanol -- adverse effects, Alcoholism, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Drug, Receptor, MESH: Binding, Competitive, Brain -- drug effects, MESH: Brain, Binding Sites -- drug effects, MESH: Alcoholism, Nervous System -- genetics, Alcoholism -- genetics, Brain -- metabolism, Messenger -- drug effects, Animals, Cannabinoid, MESH: Mice, [SDV.NEU] Life Sciences/Neurons and Cognition, GABA Agonists, MESH: RNA, Messenger, Brain Chemistry, Binding Sites, MESH: Chronic Disease, Alcoholism -- metabolism, Binding, MESH: Adaptation, Physiological, MESH: Male, Disease Models, Animal, Nervous System -- physiopathology, Disease Models, Chronic Disease, RNA, Excitatory Amino Acid Antagonists, CB1 -- deficiency, mesh: mesh:Binding, Competitive, mesh: mesh:Brain, mesh: mesh:Brain Chemistry, mesh: mesh:Receptors, GABA-A, mesh: mesh:Alcoholism, mesh: mesh:Disease Models, Animal, mesh: mesh:Adaptation, Physiological, mesh: mesh:RNA, Messenger, mesh: mesh:Muscimol, mesh: mesh:Excitatory Amino Acid Antagonists, mesh: mesh:Mice, Knockout, mesh: mesh:Protein Subunits, mesh: mesh:GABA Agonists, mesh: mesh:Chronic Disease, mesh: mesh:Mice, mesh: mesh:Receptors, N-Methyl-D-Aspartate, mesh: mesh:Ethanol, mesh: mesh:Receptor, Cannabinoid, CB1, mesh: mesh:Dose-Response Relationship, Drug, mesh: mesh:Male, mesh: mesh:Animals, mesh: mesh:Alcohol-Induced Disorders, Nervous System, mesh: mesh:Binding Sites
Male, CB1 -- genetics, Muscimol -- metabolism, MESH: Receptor, Cannabinoid, CB1, Mice, MESH: Animals, MESH: Receptors, GABA-A, MESH: Alcohol-Induced Disorders, Nervous System, Nervous System -- metabolism, Competitive -- drug effects, GABA-A -- drug effects, Muscimol, Brain, Sciences bio-médicales et agricoles, Protein Subunits -- genetics, MESH: Protein Subunits, Alcohol-Induced Disorders, Excitatory Amino Acid Antagonists -- pharmacology, MESH: Ethanol, Knockout, Physiological -- genetics, Binding, Competitive, Dose-Response Relationship, Alcohol-Induced Disorders, Nervous System, MESH: GABA Agonists, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], RNA, Messenger, Adaptation, MESH: Receptors, N-Methyl-D-Aspartate, Dose-Response Relationship, Drug, Ethanol, Animal, Brain Chemistry -- drug effects, Messenger -- metabolism, Protein Subunits, MESH: Binding Sites, MESH: Disease Models, Animal, Competitive -- physiology, MESH: Muscimol, MESH: Mice, Knockout, Binding Sites -- physiology, MESH: Dose-Response Relationship, Drug, Brain Chemistry -- genetics, Receptors, MESH: Brain Chemistry, GABA Agonists -- pharmacology, Mice, Knockout, Brain -- physiopathology, Alcoholism -- physiopathology, MESH: Excitatory Amino Acid Antagonists, Adaptation, Physiological, Ethanol -- adverse effects, Alcoholism, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Drug, Receptor, MESH: Binding, Competitive, Brain -- drug effects, MESH: Brain, Binding Sites -- drug effects, MESH: Alcoholism, Nervous System -- genetics, Alcoholism -- genetics, Brain -- metabolism, Messenger -- drug effects, Animals, Cannabinoid, MESH: Mice, [SDV.NEU] Life Sciences/Neurons and Cognition, GABA Agonists, MESH: RNA, Messenger, Brain Chemistry, Binding Sites, MESH: Chronic Disease, Alcoholism -- metabolism, Binding, MESH: Adaptation, Physiological, MESH: Male, Disease Models, Animal, Nervous System -- physiopathology, Disease Models, Chronic Disease, RNA, Excitatory Amino Acid Antagonists, CB1 -- deficiency, mesh: mesh:Binding, Competitive, mesh: mesh:Brain, mesh: mesh:Brain Chemistry, mesh: mesh:Receptors, GABA-A, mesh: mesh:Alcoholism, mesh: mesh:Disease Models, Animal, mesh: mesh:Adaptation, Physiological, mesh: mesh:RNA, Messenger, mesh: mesh:Muscimol, mesh: mesh:Excitatory Amino Acid Antagonists, mesh: mesh:Mice, Knockout, mesh: mesh:Protein Subunits, mesh: mesh:GABA Agonists, mesh: mesh:Chronic Disease, mesh: mesh:Mice, mesh: mesh:Receptors, N-Methyl-D-Aspartate, mesh: mesh:Ethanol, mesh: mesh:Receptor, Cannabinoid, CB1, mesh: mesh:Dose-Response Relationship, Drug, mesh: mesh:Male, mesh: mesh:Animals, mesh: mesh:Alcohol-Induced Disorders, Nervous System, mesh: mesh:Binding Sites
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