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image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Alcoholism Clinical ...arrow_drop_down
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
Alcoholism Clinical and Experimental Research
Article . 1996 . Peer-reviewed
License: Wiley Online Library User Agreement
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Differential Effects of Ethanol on Feline Rage and Predatory Attack Behavior: An Underlying Neural Mechanism

Authors: Yuchan Han; Allan Siegel; Larissa Poherecky; Majid B. Shaikh; Kristie Schubert;

Differential Effects of Ethanol on Feline Rage and Predatory Attack Behavior: An Underlying Neural Mechanism

Abstract

Previous studies have shown that, at certain dose levels, ethanol can exert a powerful, facilitory effect on aggressive behavior in both animals and humans. In the cat, however, it was discovered that ethanol differentially alters two forms of aggression that are common to this species. Defensive rage behavior is significantly enhanced, whereas predatory attack behavior is suppressed by ethanol administration. One possible mechanism governing alcohol's potentiation of defensive rage behavior is that it acts on the descending pathway from the medial hypothalamus to the midbrain periaq‐ueductal gray (PAG)—an essential pathway for the expression of defensive rage behavior that uses excitatory amino acids as a neu‐rotransmitter. This hypothesis is supported by the finding that the excitatory effects of alcohol on defensive rage behavior are blocked by administration of the N‐methyl‐o‐aspartate antagonist dl‐2‐ami‐no‐7‐phosphoheptanoic acid (AP‐7) when microinjected into the periaqueductal gray, a primary neuronal target of descending fibers from the medial hypothalamus that mediate the expression of defensive rage behavior. Thus, the present study establishes for the first time a specific component of the neural circuit for defensive rage behavior over which the potentiating effects of ethanol are mediated.

Keywords

Male, Brain Mapping, Dose-Response Relationship, Drug, Ethanol, Hypothalamus, Middle, Receptors, N-Methyl-D-Aspartate, Rage, Aggression, Predatory Behavior, Neural Pathways, Cats, Animals, Periaqueductal Gray, Female, Nerve Net

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    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    17
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    impulse
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Found an issue? Give us feedback
citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
17
Average
Average
Top 10%