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Differential Effects of Ethanol on Feline Rage and Predatory Attack Behavior: An Underlying Neural Mechanism

pmid: 8865964
Previous studies have shown that, at certain dose levels, ethanol can exert a powerful, facilitory effect on aggressive behavior in both animals and humans. In the cat, however, it was discovered that ethanol differentially alters two forms of aggression that are common to this species. Defensive rage behavior is significantly enhanced, whereas predatory attack behavior is suppressed by ethanol administration. One possible mechanism governing alcohol's potentiation of defensive rage behavior is that it acts on the descending pathway from the medial hypothalamus to the midbrain periaq‐ueductal gray (PAG)—an essential pathway for the expression of defensive rage behavior that uses excitatory amino acids as a neu‐rotransmitter. This hypothesis is supported by the finding that the excitatory effects of alcohol on defensive rage behavior are blocked by administration of the N‐methyl‐o‐aspartate antagonist dl‐2‐ami‐no‐7‐phosphoheptanoic acid (AP‐7) when microinjected into the periaqueductal gray, a primary neuronal target of descending fibers from the medial hypothalamus that mediate the expression of defensive rage behavior. Thus, the present study establishes for the first time a specific component of the neural circuit for defensive rage behavior over which the potentiating effects of ethanol are mediated.
- Rutgers New Jersey Medical School United States
- Rutgers, The State University of New Jersey United States
- Center for Alcohol Studies Thailand
- Rutgers New Jersey Medical School United States
- Center for Alcohol Studies Thailand
Male, Brain Mapping, Dose-Response Relationship, Drug, Ethanol, Hypothalamus, Middle, Receptors, N-Methyl-D-Aspartate, Rage, Aggression, Predatory Behavior, Neural Pathways, Cats, Animals, Periaqueductal Gray, Female, Nerve Net
Male, Brain Mapping, Dose-Response Relationship, Drug, Ethanol, Hypothalamus, Middle, Receptors, N-Methyl-D-Aspartate, Rage, Aggression, Predatory Behavior, Neural Pathways, Cats, Animals, Periaqueductal Gray, Female, Nerve Net
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