Involvement of A2A receptors in anxiolytic, locomotor and motivational properties of ethanol in mice
Copyright policy )Involvement of A2A receptors in anxiolytic, locomotor and motivational properties of ethanol in mice
We have shown previously that mice lacking the adenosine A2A receptor (A2AR) generated on a CD1 background self‐administer more ethanol and exhibit hyposensitivity to acute ethanol. We aimed to investigate if the increased propensity of A2A−/− mice to consume ethanol is associated with an altered sensitivity in the motivational properties of ethanol in the conditioned place preference (CPP) and conditioned taste aversion (CTA) paradigms and with an altered development of sensitization to the locomotor effects of ethanol. We also tested their sensitivity to the anxiolytic effects of ethanol. Our results show that A2A−/− mice produced on a CD1 background displayed a reduced ethanol‐induced CPP and an increased sensitivity to the anxiolytic and locomotor‐stimulant effects of ethanol, but they did not show alteration in ethanol‐induced CTA and locomotor sensitization. Ethanol‐induced CPP, ethanol consumption and the locomotor effects of ethanol were also tested in A2A−/− mice produced on a C57BL/6J background. Our results emphasized the importance of the genetic background because alteration in ethanol consumption and preference, ethanol‐induced CPP and locomotor‐stimulant effects were not found in knockout mice produced on the alcohol‐preferring C57BL/6J genetic background. Finally, the A2AR agonist, 2‐p‐(2‐carboxyethyl)‐phenylethylamino‐5′‐N‐ethylcarboxamidoadenosine hydrochloride (CGS 21680), reduced ethanol consumption and preference in C57BL/6J mice. In conclusion, A2AR deficiency in mice generated on a CD1 background leads to high ethanol consumption that is associated with an increased sensitivity to the locomotor‐stimulant/anxiolytic effects of ethanol and a decrease in ethanol‐induced CPP.
Male, Adenosine, Central Nervous System Depressants -- pharmacology, Drug Resistance, Anxiety, Motor Activity -- drug effects -- physiology, MESH: Genotype, Mice, Mice, Inbred C57BL [MESH], MESH: Behavior, Animal, MESH: Animals, MESH: Alcohol-Induced Disorders, Nervous System, Brain [MESH], Behavior, Animal, Brain, MESH: Motor Activity, Anti-Anxiety Agents [MESH], Alcohol-Induced Disorders, Mice [MESH], MESH: Drug Resistance, MESH: Receptor, Adenosine A2A, MESH: Ethanol, Genotype, Knockout, MESH: Motivation, Animal -- drug effects -- physiology, Species Specificity, Alcohol-Induced Disorders, Nervous System, MESH: Species Specificity, Conditioning (Psychology) [MESH], [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Behavior, Drug Resistance [MESH], MESH: Anxiety, Ethanol, Animal, MESH: Conditioning (Psychology), MESH: Adenosine, Mice, Inbred C57BL, Adenosine A2A -- drug effects -- metabolism, MESH: Disease Models, Animal, Ethanol -- pharmacology, Central Nervous System Depressants [MESH], Nervous System -- genetics -- metabolism -- physiopathology, Anxiety [MESH], Inbred C57BL, MESH: Mice, Knockout, Behavior, Animal [MESH], Alcohol-Induced Disorders, Nervous System [MESH], Conditioning, Psychological, Genotype [MESH], Drug Resistance -- drug effects -- genetics, Adenosine [MESH], Mice, Knockout, Anti-Anxiety Agents -- pharmacology, Ethanol [MESH], Anxiety -- drug therapy -- genetics -- metabolism, Species Specificity [MESH], Animals [MESH], [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Motor Activity [MESH], Receptor, Receptor, Adenosine A2A, Brain -- drug effects -- metabolism -- physiopathology, Male [MESH], Conditioning (Psychology) -- drug effects -- physiology, Mice, Knockout [MESH], Motor Activity, MESH: Brain, MESH: Mice, Inbred C57BL, Disease Models, Animal [MESH], Animals, MESH: Mice, [SDV.NEU] Life Sciences/Neurons and Cognition, Motivation, Receptor, Adenosine A2A [MESH], Adenosine -- metabolism, Central Nervous System Depressants, Motivation [MESH], Sciences biomédicales, MESH: Male, MESH: Anti-Anxiety Agents, Disease Models, Animal, Anti-Anxiety Agents, [ SDV.NEU ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Disease Models, MESH: Central Nervous System Depressants, mesh: mesh:Conditioning (Psychology), mesh: mesh:Anti-Anxiety Agents, mesh: mesh:Brain, mesh: mesh:Motivation, mesh: mesh:Receptor, Adenosine A2A, mesh: mesh:Disease Models, Animal, mesh: mesh:Mice, Knockout, mesh: mesh:Behavior, Animal, mesh: mesh:Drug Resistance, mesh: mesh:Central Nervous System Depressants, mesh: mesh:Mice, mesh: mesh:Ethanol, mesh: mesh:Adenosine, mesh: mesh:Species Specificity, mesh: mesh:Mice, Inbred C57BL, mesh: mesh:Genotype, mesh: mesh:Anxiety, mesh: mesh:Male, mesh: mesh:Animals, mesh: mesh:Alcohol-Induced Disorders, Nervous System, mesh: mesh:Motor Activity
Male, Adenosine, Central Nervous System Depressants -- pharmacology, Drug Resistance, Anxiety, Motor Activity -- drug effects -- physiology, MESH: Genotype, Mice, Mice, Inbred C57BL [MESH], MESH: Behavior, Animal, MESH: Animals, MESH: Alcohol-Induced Disorders, Nervous System, Brain [MESH], Behavior, Animal, Brain, MESH: Motor Activity, Anti-Anxiety Agents [MESH], Alcohol-Induced Disorders, Mice [MESH], MESH: Drug Resistance, MESH: Receptor, Adenosine A2A, MESH: Ethanol, Genotype, Knockout, MESH: Motivation, Animal -- drug effects -- physiology, Species Specificity, Alcohol-Induced Disorders, Nervous System, MESH: Species Specificity, Conditioning (Psychology) [MESH], [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Behavior, Drug Resistance [MESH], MESH: Anxiety, Ethanol, Animal, MESH: Conditioning (Psychology), MESH: Adenosine, Mice, Inbred C57BL, Adenosine A2A -- drug effects -- metabolism, MESH: Disease Models, Animal, Ethanol -- pharmacology, Central Nervous System Depressants [MESH], Nervous System -- genetics -- metabolism -- physiopathology, Anxiety [MESH], Inbred C57BL, MESH: Mice, Knockout, Behavior, Animal [MESH], Alcohol-Induced Disorders, Nervous System [MESH], Conditioning, Psychological, Genotype [MESH], Drug Resistance -- drug effects -- genetics, Adenosine [MESH], Mice, Knockout, Anti-Anxiety Agents -- pharmacology, Ethanol [MESH], Anxiety -- drug therapy -- genetics -- metabolism, Species Specificity [MESH], Animals [MESH], [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Motor Activity [MESH], Receptor, Receptor, Adenosine A2A, Brain -- drug effects -- metabolism -- physiopathology, Male [MESH], Conditioning (Psychology) -- drug effects -- physiology, Mice, Knockout [MESH], Motor Activity, MESH: Brain, MESH: Mice, Inbred C57BL, Disease Models, Animal [MESH], Animals, MESH: Mice, [SDV.NEU] Life Sciences/Neurons and Cognition, Motivation, Receptor, Adenosine A2A [MESH], Adenosine -- metabolism, Central Nervous System Depressants, Motivation [MESH], Sciences biomédicales, MESH: Male, MESH: Anti-Anxiety Agents, Disease Models, Animal, Anti-Anxiety Agents, [ SDV.NEU ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Disease Models, MESH: Central Nervous System Depressants, mesh: mesh:Conditioning (Psychology), mesh: mesh:Anti-Anxiety Agents, mesh: mesh:Brain, mesh: mesh:Motivation, mesh: mesh:Receptor, Adenosine A2A, mesh: mesh:Disease Models, Animal, mesh: mesh:Mice, Knockout, mesh: mesh:Behavior, Animal, mesh: mesh:Drug Resistance, mesh: mesh:Central Nervous System Depressants, mesh: mesh:Mice, mesh: mesh:Ethanol, mesh: mesh:Adenosine, mesh: mesh:Species Specificity, mesh: mesh:Mice, Inbred C57BL, mesh: mesh:Genotype, mesh: mesh:Anxiety, mesh: mesh:Male, mesh: mesh:Animals, mesh: mesh:Alcohol-Induced Disorders, Nervous System, mesh: mesh:Motor Activity
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