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Genes Brain & Behavior
Article . 2009 . Peer-reviewed
License: Wiley Online Library User Agreement
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Amygdala protein kinase C epsilon controls alcohol consumption

Authors: Heidi M. B. Lesscher; Robert O. Messing; Melisa J. Wallace; Lily Zeng; Victoria E. Wang; J. K. Deitchman; Philip M. Newton; +1 Authors

Amygdala protein kinase C epsilon controls alcohol consumption

Abstract

Alcoholism is a progressive disorder that involves the amygdala. Mice lacking protein kinase C epsilon (PKCɛ) show reduced ethanol consumption, sensitivity and reward. We therefore investigated whether PKCɛ signaling in the amygdala is involved in ethanol consumption. Local knockdown of PKCɛ in the amygdala reduced ethanol consumption and preference in a limited‐access paradigm. Further, mice that are heterozygous for the PKCɛ allele consume less ethanol compared with wild‐type mice in this paradigm. These mice have a >50% reduction in the abundance of PKCɛ in the amygdala compared with wild‐type mice. We conclude that amygdala PKCɛ is important for ethanol consumption in mice.

Countries
Netherlands, United Kingdom
Keywords

Male, Knockout, Protein Kinase C-epsilon, Inbred C57BL, Nervous System, Conditioning (Psychology), Mice, Alcohol-Induced Disorders, Nervous System, Gene Frequency, Reward, Conditioning, Psychological, Animals, Genetic Predisposition to Disease, Brain Chemistry, Mice, Knockout, Ethanol, Animal, Central Nervous System Depressants, Amygdala, Alcohol-Induced Disorders, Mice, Inbred C57BL, Alcoholism, Disease Models, Animal, Disease Models

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    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    47
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 10%
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
47
Top 10%
Top 10%
Top 10%
Green
bronze
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