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Amygdala protein kinase C epsilon controls alcohol consumption

Alcoholism is a progressive disorder that involves the amygdala. Mice lacking protein kinase C epsilon (PKCɛ) show reduced ethanol consumption, sensitivity and reward. We therefore investigated whether PKCɛ signaling in the amygdala is involved in ethanol consumption. Local knockdown of PKCɛ in the amygdala reduced ethanol consumption and preference in a limited‐access paradigm. Further, mice that are heterozygous for the PKCɛ allele consume less ethanol compared with wild‐type mice in this paradigm. These mice have a >50% reduction in the abundance of PKCɛ in the amygdala compared with wild‐type mice. We conclude that amygdala PKCɛ is important for ethanol consumption in mice.
- University of California, San Francisco United States
- Ernest Gallo Clinic and Research Center United States
- University of California System United States
- Ernest Gallo Clinic and Research Center United States
- Utrecht University Netherlands
Male, Knockout, Protein Kinase C-epsilon, Inbred C57BL, Nervous System, Conditioning (Psychology), Mice, Alcohol-Induced Disorders, Nervous System, Gene Frequency, Reward, Conditioning, Psychological, Animals, Genetic Predisposition to Disease, Brain Chemistry, Mice, Knockout, Ethanol, Animal, Central Nervous System Depressants, Amygdala, Alcohol-Induced Disorders, Mice, Inbred C57BL, Alcoholism, Disease Models, Animal, Disease Models
Male, Knockout, Protein Kinase C-epsilon, Inbred C57BL, Nervous System, Conditioning (Psychology), Mice, Alcohol-Induced Disorders, Nervous System, Gene Frequency, Reward, Conditioning, Psychological, Animals, Genetic Predisposition to Disease, Brain Chemistry, Mice, Knockout, Ethanol, Animal, Central Nervous System Depressants, Amygdala, Alcohol-Induced Disorders, Mice, Inbred C57BL, Alcoholism, Disease Models, Animal, Disease Models
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).47 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
