Electrical submersible pumps (ESPs) are widely used in upstream oil production. The presence of a low concentration solid phase, particle-laden flow, in the production fluid may cause severe damage in the internal sections of the pump which reduces its operating lifetime. To better understand the ESP pump's endurance, two different designs of commonly used mixed flow ESPs were studied numerically to determine the pump's flow behavior at its best efficiency point. Computational fluid dynamics (CFD) analysis was conducted on two stages of one design type of pump's primary flow path employing Eulerian–Granular scheme in ANSYS FLUENT. The key parameters affecting the erosion phenomena within the pump such as turbulence kinetic energy, local sand concentration, and near wall relative sand velocity were identified. The predictive erosion model applicable to pumps was developed by correlating the erosion key parameters with available experimental results. It is concluded that the use of an erosion model on the second design of ESP proves the model's versatility to predict the erosion on different designs of ESPs.