This paper deals about the application of MILP for economic optimization of complex cogenerative systems. In particular, it optimizes both the size and operating strategy of CHP systems and the lay-out of micro district heating networks applied to a urban contest. The proposed model considers the possible adoption of a set of micro-cogeneration gas turbines located in different buildings, and of a centralized cogeneration system thus allowing part of the required thermal energy to be produced in a single site. In addition, thermal and photovoltaic panels can be integrated into the system to improve thermal and electrical energy production, respectively. Each site can be connected to the others through district heating micro-grids. Hence thermal energy can be distributed inside the system. A further objective of the paper is to evaluate the effect of different economic support policies on the optimal solution, and to relate the economic effort implied in each support policy with the expected results in terms of CO2 emissions reduction and primary energy savings.