Semiconductors with nanoscale dimensions are indispensable vectors for devising modern-age electronics-enabled technologies. Meeting the rising technological demand of the globally expanding population, while limiting the cost to the ecosystem, necessitates the sustainable development of green semiconductors at the nanoscale. This perspective highlights the state-of-the-art green nano-semiconductors, including metal oxides, organic materials, and hybrid nanosystems, with three key challenges: scalability, stability, and susceptibility. It also discusses alternate solutions integrating modern technologies like artificial intelligence to establish these green nano-semiconductors as a sustainable frontier to revolutionize multidimensional applications such as sensors, medicines, electronics, energy systems, and environmental remediation while minimizing ecological footprints.