The theme of this article is to scrutinize the entropy rate in hydromagnetic flow of Reiner–Philippoff nanofluid by a stretching surface. Energy equation is developed through first law of thermodynamic with dissipation and Joule heating. Furthermore, random and thermophoretic motion is discussed. Additionally, binary reaction is discussed. Physical feature of irreversibility analysis is discussed. Nonlinear expression is obtained by suitable transformation. The obtained systems are solved through the numerical method (bvp4c). Variation of entropy rate, thermal field, velocity profile, and concentration against sundry variables are discussed. Computational outcomes of thermal and mass transport rate for influential parameters are studied in tabularized form. A reverse effect holds for thermal field and velocity through magnetic variable. Higher Bingham number leads to a rise in velocity field. An intensification in thermal field and concentration is noted for thermophoretic variable. An enhancement in fluid variable leads to augments velocity. An increment in entropy analysis is seen for magnetic effect. Larger estimation of diffusion variable improves entropy rate. A reduction in concentration is noticed for reaction variable.