Stress in medical students is a burning issue these days, prolonged stress among students is leading to different psychological disorders. The aim of the present study is to make a comparison of the stress levels experienced between a government medical college’s students and private medical college’s students of Guntur district, Andhra Pradesh. The total sample size of the study was 507. Findings of the study revealed that there is a significant difference between the stress experienced by government medical college students and private medical college students. Respondents were using different coping mechanisms like going to shopping/movies/watch TV/internet/listening to music to relax, keeping the sense of humor, etc., to overcome the stress. Attention should be paid to the students to address this issue.