Abstract Understanding precipitation properties at regional scales and generating reliable future projections is crucial in providing actionable information for decision-makers, especially in regions with high vulnerability to climate change, where future changes impact ecosystem resilience, biodiversity, agriculture, water resources and human health. The South America Convection-Permitting Regional Climate Model experiment (SA-CPRCM) examines climate change effects in convection-permitting simulations at 4.5 km resolution, on climate time scales (10 years of present-day and RCP8.5 2100), over a domain covering most of South America, using the Met Office Unified Model (UM) convection-permitting RCM. Under the RCP8.5 scenario, precipitation in the CPRCM decreases, becomes less frequent and more seasonal over the Eastern Amazon region. Dry spells lengthen, increasing the risk of drought. In the Western Amazon, precipitation increases in the wetter austral autumn (Apr. – Jun.) and decreases in the drier austral winter and spring (July – Oct.), leading to a more distinct dry season and imposing a greater risk of contraction of the tropical forest. Over South-eastern Brazil, future precipitation increases and becomes more frequent and more intense, increasing the risk of floods and landslides. A future increase in the intensity of precipitation and extremes is evident over all these regions, regardless of whether the mean precipitation is increasing or decreasing. The CPRCM and its driving GCM respond in a similar way to the future forcing. The models produce broadly similar large-scale spatial patterns of mean precipitation and comparable changes to frequency, intensity, and extremes, although the magnitude of change varies by region and season.