The feasibility and consequences of replacing nuclear power plants (NPP) in the Czech Republic with other energy sources are discussed. The NPP produced about one-third of electricity in the Czech Republic in 2017. Renewable energy sources such as hydropower, wind and solar power plants and biomass/biogas burning power plants produced about 11% of electricity in 2017. Due to the geographical and other constraints (intermittency, land footprint, and public acceptance), the renewables do not have the potential to entirely replace the capacity of the NPP. The only feasible technologies that could replace NPP in the Czech Republic in the near future are the power plants using fossil fuels. The combined cycle power plants running on natural gas (NGCC) are technically and environmentally fea-sible alternative for NPP at the moment. However, the natural gas imports would increase by two-thirds and the total greenhouse gas emissions would go up by about 10% if the power production of the NPP was entirely replaced by NGCC in the Czech Republic.