Improving the organizational and economic mechanism for ensuring the sustainable development of the region in the context of decentralization is an extremely urgent problem. National concept of sustainable development of settlements (defines the main directions of state policy on ensuring sustainable development of settlements, legal and economic ways of their implementation) and the strategy of sustainable development of Ukraine – 2020 (defines the purpose, traffic vectors, roadmap, priority priorities and indicators of proper defense, socio-economic, organizational, political and legal conditions for the formation and development of Ukraine) are roadmaps for the regions, but the programs of implementation of the set tasks and achievement in such indicators should be formed on the ground, taking into account the peculiarities of socio-economic, geopolitical, demographic and other factors of development of the region in time and space. Important in this sense is the constant monitoring of the socio-economic status of the region, the results of which allow to establish effective economic and organizational and legal mechanisms of regional policy-making.