Optimization of energy consumption and related energy efficiency can be realized in various ways, both through measures to reduce heat losses through building partitions and the introduction of modern systems of regulation and management of heat distribution. In order to achieve the best possible results, these actions should be interlinked, especially in older buildings that have undergone thermomodernization. Therefore, the aim of the study was to evaluate actions aimed at improving energy efficiency of buildings made in prefabricated technology. These buildings were thermomodernized and then the weather-controlled central heating system was installed. The study assessed whether the application of the change of the method of central heating regulation from the traditional one, taking into account only the change of external temperature to the weather-controlled one, will contribute to the increase of energy efficiency of buildings. The research was carried out in the existing residential buildings, for which data on the actual energy consumption was collected and elaborated and includes periods before modernization, after thermomodernization and the period after the introduction of the central heating system with weather control. The collected data cover an eighteen-year period of buildings’ use. The obtained results indicate that in Polish conditions the introduction of weather-controlled regulation system in buildings made in prefabricated technology (made of large slab) allows to achieve energy savings in the range of 16–23%, it may be related to their high thermal capacity resulting from the use of concrete elements in the building envelope.