When examining the history of wind engineering, it is evident that many full-scale/model test comparisons have found noticeable differences between the results. Although understanding the causes of these differences is important for practical purposes, limited numerical and experimental conditions have often resulted in subjective explanations for full-scale/model test comparisons without scientific validation. To address this issue, this article suggests the use of the computational fluid dynamics technique or the multiple-fan actively controlled wind tunnel technique to quantitatively reveal the adverse effects that impact the reliability of the traditional atmospheric boundary layer wind tunnel tests for a large cooling tower, including not only the widely acknowledged influences (Reynolds number effects and turbulent flow characteristics effects) but also the non-stationarity effects that have potential influences. Established on the novel proposition, a new research scheme for future full-scale/model test wind effects comparisons for large cooling towers has been formulated based on the numerical or physical simulations of the sinusoidal flow fields. Using the Pengcheng cooling tower as a case study, the research recognized the very significant impact of Reynolds number effects, the non-stationarity effects that cannot be ignored, and the negligible effects of turbulent flow characteristics.