In this paper, a multibody calculation methodology has been applied to the vibration analysis of a 4-cylinder, 4-stroke, turbocharged diesel engine, with a simulation driven study of the angular speed variation of a crankshaft under consideration of different modeling assumptions. Moreover, time dependent simulation results, evaluated at the engine supports, are condensed to a vibration index and compared with experimental results, obtaining satisfactory outcomes. The modal analysis also considers the damping aspects and has been conducted using a multibody model created with the software AVL/EXCITE. The influence of crankshaft torsional frequencies on the rotational speed behavior has been evaluated in order to reduce the vibration phenomena. The focus of this work is related to industrial aspects since, for an existing and commercialized engine, a numerical and experimental complex study has been performed to enable design improvements aimed at reducing noise and vibrations. Existing procedures and algorithms are combined here to reach the abovementioned objectives in the most efficient way.