Using renewable energy to convert CO2 to a clean fuel ethanol can not only reduce carbon emission through the utilization of CO2 as feedstock, but also store renewable energy as the widely used chemical and high-energy-density fuel, being considered as a perfect strategy to address current environment and energy issues. Developing efficient electrocatalysts, photocatalysts, and photoelectrocatalysts for CO2 reduction is the most crucial keystone for achieving this goal. Considerable progresses in CO2-based ethanol production have been made over the past decades. This review provides the general principles and summarizes the latest advancements in electrocatalytic, photocatalytic and photoelectrocatalytic CO2 conversion to ethanol. Furthermore, the main challenges and proposed future prospects are illustrated for further developments in clean fuel ethanol production.