Demand response (DR) is known as a key solution in modern power systems and electricity markets for mitigating wind power uncertainties. However, effective incorporation of DR into power system operation scheduling needs knowledge of the price–elastic demand curve that relies on several factors such as estimation of a customer’s elasticity as well as their participation level in DR programs. To overcome this challenge, this paper proposes a novel autonomous DR scheme without prediction of the price–elastic demand curve so that the DR providers apply their selected load profiles ranked in the high priority to the independent system operator (ISO). The energy and reserve markets clearing procedures have been run by using a multi-objective decision-making framework. In fact, its objective function includes the operation cost and the customer’s disutility based on the final individual load profile for each DR provider. A two-stage stochastic model is implemented to solve this scheduling problem, which is a mixed-integer linear programming approach. The presented approach is tested on a modified IEEE 24-bus system. The performance of the proposed model is successfully evaluated from economic, technical and wind power integration aspects from the ISO viewpoint.