The electricity sector foresees a significant change in the way energy is generated and distributed in the coming years. With the increasing penetration of renewable energy sources, smart algorithms can determine the difference about how and when energy is produced or consumed by residential districts. However, managing and implementing energy demand response, in particular energy flexibility activations, in real case studies still presents issues to be solved. This study, within the framework of the European project “SABINA H2020”, addresses the development of a multi-level optimization algorithm that has been tested in a semi-virtual real-time configuration. Results from a two-day test show the potential of building’s flexibility and highlight its complexity. Results show how the first level algorithm goal to reduce the energy injected to the grid is accomplished as well as the energy consumption shift from nighttime to daytime hours. As conclusion, the study demonstrates the feasibility of such kind of configurations and puts the basis for real test site implementation.