Combined heat and power systems (CHP) produce heat and electricity simultaneously. Their resulting high efficiency makes them more attractive from the energy managers’ perspective than other conventional thermal systems. Although heat is a by-product of the electricity generation process, system operators usually operate CHP systems to satisfy heat demand. Electricity generation from CHP is thus driven by the heat demand, which follows the variability of seasonal temperature, and thus is not always correlated with the fluctuation of electricity demand. Consequently, from the perspective of the electricity grid operator, CHP systems can be seen as a non-controllable energy source similar to other renewable energy sources such as solar, wind or hydro. In this study, we investigate how ‘non-controllable’ electricity generation from CHP systems combines with ‘non-controllable’ electricity generation from solar photovoltaic panels (PV) and run-of-the river (RoR) hydropower at a district level. Only these three energy sources are considered within a 100% renewable mix scenario. Energy mixes with different shares of CHP, solar and RoR are evaluated regarding their contribution to total energy supply and their capacity to reduce generation variability. This analysis is carried out over an ensemble of seventeen catchments in North Eastern Italy located along a climate transect ranging from high elevation and snow dominated head-water catchments to rain-fed and wet basins at lower elevations. Results show that at a district scale, integration of CHP systems with solar photovoltaic and RoR hydropower leads to higher demand satisfaction and lower variability of the electricity balance. Results also show that including CHP in the energy mix modifies the optimal relative share between solar and RoR power generation. Results are consistent across the climate transect. For some districts, using the electricity from CHP might also be a better solution than building energy storage for solar PV.