In this study, a modified non-uniform adiabatic section in a Two-Phase Closed Thermosiphon (TPCT) is proposed where the uniform section was replaced by convergent and divergent (C-D) sections. The heat transfer analysis was performed on the modified TPCT and their findings were compared with standard TPCT. The deionized water (DI) in the proportion of 30 vol% is filled in both the TPCTs. Further, the heat transfer performance analysis was carried out for three different orientations, such as 0°, 45° and 90°, and heat input was varied from 50 to 250 W. The effect of these geometrical changes and inclination angles on the heat transfer performance of both the TPCT were evaluated to compare the thermal resistance, wall temperature variation and heat transfer coefficient. The non-dimensional numbers such as Weber (WE), Bond (BO), Condensation (CO) and Kutateladze (KU) were investigated based on heat fluxes for both TPCTs. By introducing the convergent-divergent section nearer to the condenser, the pressure before and after the C-D section was increased and decreased. This enhances the heat transfer in the evaporator slightly up to 2% and 1.4% at horizontal and 45° orientation, respectively, in Non-Uniformed Adiabatic Section (NUAS) TPCT when compared to Uniformed Adiabatic Section (UAS) TPCT. The thermal resistance of NUAS TPCT was reduced by up to 4.5% relative to UAS TPCT in horizontal and 45°. The results of the non-dimensional number also confirmed that NUAS TPCT provided better performance by enhancing 2% more pool boiling characteristics, interaction forces and condensate returns. Several factors such as gravity assistance, fluid accumulation, pressure drop and thermal resistance exert an influence on the heat transfer performance of the proposed NUAS TPCT at various orientation angles. However, different type of cross-sectional variations subjected to orientation changes may also get influenced by several other parameters that in turn affect the heat transfer performance distinctly.