The article presents the results of research on the vibroacoustic response of internal combustion engines mounted in a vehicle. The vehicles studied belong to popular models, which became available in successive versions. Each group included vehicles of the same model of an older generation (equipped with a naturally aspirated engine) and of a newer generation, including downsized (and turbocharged) engines. Tests in each group were carried out under repeatable conditions on a chassis-load dynamometer. The vibrations were measured using single-axis accelerometers mounted on the steering wheel, engine, and driver’s head restraint mounting. The primary purpose of the study was to verify whether the new generations of vehicles equipped with additional high-speed elements (compressors) generate additional harmonics (especially those within the range potentially affecting travel comfort and human health) and whether there are significant changes in the distribution of spectral power density in the new generations. As the study showed, new generations of vehicles are characterized by a different vibroacoustic response, and the trend of change is the same in each of the families studied.