Nuclear power can replace fossil fuels and will have a decisive impact on the change in the approach to conventional energy. However, nuclear (or radioactive) wastes are produced by the operation of the nuclear reactors should be safely and properly disposed of. This paper assesses the uranium resources and the global state of nuclear power plants and determines the energy mixes in different countries using the most nuclear energy. Furthermore, this paper analysed the nuclear waste management and disposal and the depletion of abiotic resources, and the primary energy sources of a basic production process using electricity mix and nuclear electricity for a basic production (PET bottle manufacturing) process. The life cycle assessment was completed by applying the GaBi 8.0 (version 10.6) software and the CML method. In this study, we limit our discussion to high-level nuclear waste (HLW) and spent nuclear fuel (SNF) waste. We do not consider waste generated from uranium mining and milling, which is usually disposed of in near-surface impoundments close to the mine or the mill. The investigation of waste management methods is limited to European countries. This research work is relevant because determining abiotic resources is important in a life cycle assessment and current literature available on LCA analysis for nuclear powers remains under-developed. These results can guide and compare manufacturing processes involving a nuclear electricity and electricity grid mix input. The results of this research can be used to develop production processes using nuclear energy with lower abiotic depletion impacts. This research work facilitates the industry in making predictions for a production-scale plant using an LCA of production processes with nuclear energy consumption.