The article presents the justification for the necessity to use chassis dynamometers in the tuning process of dual-fuel trucks. The research system used and the research methodology are presented. The research results present the approach to solving problems related to setting the technical (physical) data of the tested vehicle on the dynamometer, selection of the vehicle engine operation range, the impact of the value of the forced load on the vehicle drive axle, selection of the dyno operation mode for the expected tasks and the impact of the correctness of the selection of the scope of the analysis of data on losses in the drive system. The article shows the above-mentioned influence on the test results on the dynamometer and on the tuning results. The article closes with a conclusion detailing prospects for developing the presented results.