Urban metabolism has emerged over the past decades as an important new paradigm of regional and urban sustainability governance towards a Chinese national scheme of ‘carbon neutrality’ by 2060. Hebei province in China faces twin pressures related to its supply of water and energy resources, which has brought humans and nature into conflict. Overcoming this tension in the human-land relationship in Hebei and determining a suitable development path for the future has become a core issue for the achievement of coordinated development within the Beijing–Tianjin–Hebei region. This paper constructs a system to simulate the metabolism of water, energy, and human relationships, and uses this model to carry out simulations for Hebei province. The model establishes five scenarios: a natural development scenario, economic growth scenario, water conservation development scenario, energy conservation development scenario, and low carbon scenario. The simulation results show that, without intervention, the natural development scenario results in greater pressure on supply gaps and a greater demand for water and energy, with more production of industrial waste gas and domestic wastewater discharges. The economic growth, water conservation development, and energy conservation development scenarios focus on single economic, water conservation, and energy conservation measures by looking at core economic, water, and energy elements within the metabolic system; however, solving issues with individual elements merely leads to other, remaining problems. Under the low carbon scenario, issues with multiple elements in Hebei’s metabolic system are considered more comprehensively, so the simulation results are better than those in the other scenarios, and it better fits the future orientation of sustainable development of Hebei province.