The current paper proposes a novel multi-generation system, integrated with compound parabolic collectors and a biomass combustor. In addition to analyzing the comprehensive system in a steady state, the feasibility of using nanofluids as heat transfer fluids in the solar cycle and their effect on the overall performance of the system was studied. The multi-generation system is generally designed for generating electricity, cooling, freshwater, drying, hot water, and hydrogen, with the help of six subsystems. These include a double stage refrigeration system, an organic Rankine cycle, a steam Rankine cycle, a dryer, a proton exchange membrane electrolyzer, and a multistage flash distillation system. Two types of nanoparticles (graphene, silver), which have various high-quality properties when used within ethylene glycol, were chosen as absorbing fluids in the solar cycle. The performance parameters of the base case thermodynamic analysis and some of the variable parameters were calculated, and their effect on system performance was determined. According to the results, a spike in solar irradiation, ambient temperature, output temperature of biomass combustor and nanofluids’ concentration positively affected the overall system performance. The results also clearly showed an improvement in system performance when using nanofluids as working fluids in solar collectors.