Greenhouses with efficient controlled environment offer a promising solution for food security against the impacts of increasing global temperatures and growing water scarcity. However, current technologies used to achieve this controlled environment consume a significant amount of energy, which impacts on operational costs and CO2 emissions. Using advanced metal organic framework materials (MOFs) with superior water adsorption characteristics, this work investigates the development of a new technology for a greenhouse-controlled environment. The system consists of MOF coated heat exchanger, air to air heat exchanger, and evaporative cooler. A three-dimensional computational fluid dynamics (CFD) model was developed using COMSOL software and experimentally validated for the MOF-801/Graphene coated heat exchanger (DCHE) to determine the best cycle time and power input. It was found that using desorption time of 16 min and power input of 1.26 W, the maximum water removal rate was obtained from MOF-801/Graphene of 274.4 g/kgMOF/W.hr. In addition, an overall mathematical model for the greenhouse climate control was developed and used to investigate the effects of air humidity and velocity on the input air conditions to the greenhouse. Results showed that with high relative humidity levels of 90% in the greenhouse can be conditioned to reach the required relative humidity of 50%.