The 2030 zero-net emission target in the E.U. demands a significant improvement in the energy performance of the building stock. This study analyses the adoption of connected thermostats and Home energy-management system solutions (HEMS) as an effective means to tackle the residential energy footprint. It reviews the main features of HEMS systems in terms of technology, cross-study performances, and the obstacles to widespread adoption; the study adopts the case-study methodology to examine the impact on the Italian real estate stock at a regional level. A matrix of adoption scenarios assesses the potential benefits of global residential energy savings, weighted by local climatic variations, dimension, number of single dwellings, and average primary energy reduction per household. Results demonstrate that all adoption scenarios dramatically reduce residential energy consumption, outperforming the E.U. targets for Italy by 2030.