With the reduction in fossil fuels and growing concerns about global warming, energy has become one of the most important issues facing humanity. It is crucial to improve energy utilization efficiency and promote a low-carbon transition. In comparison with traditional heat exchangers, heat pipe heat exchangers indicate high compactness, a flexible arrangement, complete separation of hot and cold fluids, good isothermal operations, etc. As a result, heat pipe heat exchangers have attracted wide attention and application in various fields in recent years. This paper provides an overview of the application of heat pipe heat exchangers, with a focus on the application in waste heat recovery, and analyzes the opportunities and challenges of heat pipe heat exchanger applications based on existing publications.