In this study, three-dimensional simulations were conducted on a new passive micromixer to assess the thermal and hydrodynamic behaviors of Newtonian and non-Newtonian fluids subjected to low generalized Reynolds numbers (0.1 to 50) and shear-thinning properties. To acquire a more profound comprehension of the qualitative and quantitative fluctuations in fluid fraction using the CFD Fluent Code, the mass mixing index, rheological behavior, performance index, mixing energy cost, mass fraction distributions, temperature contours, and pressure drop were compared to illustrate the importance of the mixer geometry in the context of two miscible fluids with varying inlet temperatures. The selected geometry is characterized by a robust chaotic flow that substantially enhances thermal and hydrodynamic performance across all Reynolds numbers. A mass mixing exceeding 72.5% is obtained when Re = 5, reaching 93.5% when Re = 50. Furthermore, the evolution of thermal mixing for all behavior indexes reaches a step of 98% with minimal pressure losses. This work enabled the demonstration of a chaotic geometry in a highly efficient mixing system, leading to enhanced thermal performance for both Newtonian and non-Newtonian fluids. The results of the hydrodynamic and thermal characterization of the mixing of shear-thinning fluids within the micromixers under investigation are conclusive.