In the field of CO2 capture and sequestration, ensuring the safety of pipeline infrastructure is paramount to successful climate change mitigation efforts. This study investigates the dynamics of CO2 dispersion from pipeline systems, assessing not only the transport process but also the physical properties and associated hazards. Advanced simulation techniques are used to model how different states of CO2 (gas, liquid, and supercritical) and varying pipeline characteristics—such as perforation sizes, flow rates, and orientations—affect the dispersion patterns in the event of a leak. Simulations cover a range of atmospheric conditions, emphasizing the role of atmospheric stability and wind speed in shaping dispersion and defining potential impact zones. An analysis of historical pipeline accidents is included to inform risk management strategies. The results show that the orientation of the pipeline has a significant effect on dispersion, with downward leaks causing the largest impact zones, particularly under supercritical conditions. The results highlight the need for adaptive safety strategies that take into account real-time CO2 transport conditions and localized environmental data. By integrating these factors, the study recommends refining safety protocols and emergency response strategies to improve pipeline resilience and public safety against potential leaks. Key findings include the quantification of the relationship between leak parameters and dispersion areas, providing a valuable framework for future safety improvements.