The effective management of waste-activated sludge (WAS) presents a significant challenge for wastewater treatment plants (WWTPs), primarily due to the sludge’s high content of organic matter, pathogens, and hazardous substances such as heavy metals. As urban populations and industrial activities expand, the increasing volume of WAS has intensified the need for sustainable treatment solutions. Conventional approaches, such as landfilling and anaerobic digestion, are frequently ineffective and resource-intensive, particularly when dealing with the protective extracellular polymeric substances (EPS) that render WAS resistant to biodegradation. Thermal pretreatment methods have gained attention due to their ability to enhance the biodegradability of sludge, improve dewaterability, and facilitate resource recovery. These processes function by breaking down complex organic structures within the sludge, thereby increasing its accessibility for subsequent treatments such as anaerobic digestion. The integration of thermal treatment with chemical methods can further optimize the management process, resulting in higher biogas yields, reduced pathogen content, and lower environmental risks. While thermal disintegration is energy-intensive, advancements in energy recovery and process optimization have made it a more viable and environmentally friendly option. This approach offers a pathway to more sustainable and efficient sludge management practices, which align with the goals of reducing waste and complying with stricter environmental regulations.