The European building sector significantly contributes to the EU’s greenhouse gas reduction goals, with the 2024 Energy Performance of Buildings Directive (EPBD) aiming to achieve a decarbonised building stock by 2050. By focusing on an existing office building representative of the Italian building stock, this research evaluates various energy efficiency measures and integrates renewable energy systems to transform the building into a Zero-emission Building (ZeB). Moreover, it also utilises future weather data to address the effects of climate change. Results highlight the actions needed for an empirical ZeB transition, offering insights into challenges and key performance indicators across different intervention scenarios. The findings contribute to establishing national ZeB standards, emphasising the importance of the national building renovation plan in compliance with the EPBD recast requirements.