The presence of natural gas hydrates at all active and passive continental margins has been proven. Their global occurrence as well as the fact that huge amounts of methane and other lighter hydrocarbons are stored in natural gas hydrates has led to the idea of using hydrate bearing sediments as an energy resource. However, natural gas hydrates remain stable as long as they are in mechanical, thermal and chemical equilibrium with their environment. Thus, for the production of gas from hydrate bearing sediments, at least one of these equilibrium states must be disturbed by depressurization, heating or addition of chemicals such as CO2. Depressurization, thermal or chemical stimulation may be used alone or in combination, but the idea of producing hydrocarbons from hydrate bearing sediments by CO2 injection suggests the potential of an almost emission free use of this unconventional natural gas resource. However, up to now there are still open questions regarding all three production principles. Within the framework of the German national research project SUGAR the thermal stimulation method by use of in situ combustion was developed and tested on a pilot plant scale and the CH4-CO2 swapping process in gas hydrates studied on a molecular level. Microscopy, confocal Raman spectroscopy and X-ray diffraction were used for in situ investigations of the CO2-hydrocarbon exchange process in gas hydrates and its driving forces. For the thermal stimulation a heat exchange reactor was designed and tested for the exothermal catalytic oxidation of methane. Furthermore, a large scale reservoir simulator was realized to synthesize hydrates in sediments under conditions similar to nature and to test the efficiency of the reactor. Thermocouples placed in the reservoir simulator with a total volume of 425 L collect data regarding the propagation of the heat front. In addition, CH4 sensors are placed in the water saturated sediment to detect the distribution of CH4 in the sample. These data are used for numerical simulations for up-scaling from laboratory to field conditions. This study presents the experimental set up of the large scale reservoir simulator and the reactor design. Preliminary results indicate that the catalytic oxidation of CH4 operated as a temperature controlled, autothermal reaction in a countercurrent heat exchange reactor is a safe and promising tool for the thermal stimulation of hydrates. In addition, preliminary results from the laboratory studies on the CO2-hydrocarbon swapping process in simple and mixed gas hydrates are presented.