The key to the successful and sustainable utilisation of non-timber forest products (NTFPs) by local communities lies in understanding their perspectives on climate change and its effects on NTFP production. Furthermore, assessing their perceptions of the diverse uses and potential for the value addition of NTFPs is crucial for determining how these resources can enhance the well-being of local livelihoods. Although studies on climate change, value addition, and the multiple uses of NTFPs and their impact on local livelihoods have been conducted, locals’ perceptions of these factors have not been fully explored. This study aims to assess various social factors, including education, gender, and religion, and their influence on locals’ perceptions of the abovementioned factors. The research focused on five regions where NTFPs are prevalent in Ghana (the Western North, Bono, Ahafo, Ashanti, and Eastern regions). To investigate the influence of social factors on local perceptions of climate change, value addition, and the multiple values of NTFPs within rural communities, a total of 732 locals were randomly selected with a team of interviewers across these five regions in Ghana. Key informant interviews and focus group interview methods were used for the data collection. We applied a logistic regression model to assess the social factors and their influencing locals’ perceptions of the mentioned variables. It was revealed that age, gender, education, and occupation did not significantly influence locals’ perceptions of climate change. However, religion was found to influence locals’ perceptions of climate change. Furthermore, the results demonstrated that gender and education strongly influenced locals’ perceptions of value addition to NTFPs. In contrast, religion and constraints (related to time, finance, and skills) did not significantly influence locals’ perceptions. In conclusion, this study provides valuable insights into the intricate interplay among local perceptions, climate change, value addition, multiple uses of NTFPs, and the capacity of NTFPs to enhance the well-being of forest fringe communities. These findings underscore the importance of comprehensive, tailor-made interventions that consider local perspectives and adhere to sustainable approaches, with the aim of optimising the positive impacts of NTFPs in poverty alleviation and overall community development.