There have been several incidences of flood recently, which are believed to be aggravated by increased climatic variables as a result of perceived changes in climatic conditions (due to climate change) in the Cross River Basin. The basin is the most extensively developed and used river basin in the management of the water resources of the Cross River and Akwa Ibom States in Nigeria. In this paper, 30 years (from 1992 to 2021) of hydro-meteorological data (annual average rainfall, maximum and minimum temperatures, hu midity, duration of sunlight (sunshine hours), evaporation, wind speed, soil temperature, cloud cover, solar radiation, and atmospheric pressure) from four stations in the Cross River Basin were obtained from the Nigerian Meteorological Agency (NIMET), Abuja and subjected to trend detection analysis using the Mann–Kendall test to determine the trend in climatic parameters. The results indicate that there is a significant upward trend in annual rainfall in Ogoja but a downward trend in Calabar. The evaporation trend is significantly downward in Eket, whereas in Calabar, there is an upward trend in solar radiation. Generally, there is a significant rise in annual maximum temperature across the basin. Serial correlation and segmented regression analyses were performed to measure the impact of fluctuations in monthly and long-term Tahiti and Darwin’s Sea level pressures on the climatic variables at the Cross River Basin catchment. These analyses were necessary to determine the extent of the influence of the El Nino Southern Oscillation climatic cycle. The analyses show no significant association between the El Niño Southern Oscillation (ENSO) and rainfall or between the ENSO and runoff in the catchment. This implies that the impact of the ENSO on rainfall and runoff in the Cross River Basin catchment is not considerable. The intercepts derived from the segmented regression in Eket and Ogoja show significant positive trends in both areas for rainfall and runoff. The trends in intercepts suggest that there are external factors influencing rainfall and runoff other than ENSO events, thus strengthening the assertion of climate change. Results from this study will facilitate the understanding of the variability in climatic parameters by stakeholders in the basin, researchers, policymakers, and water resource managers.