With ambitious targets set by the EU for the reduction of emissions from the energy sector by 2030, there is a need to design and develop more building projects using renewable energy sources. Even though in Europe, heating and cooling share from renewable resources is increasing, and in 2021, the total share in this sector in Croatia was at 38%, the share of heat production by heat pumps is rather low. One possibility to increase this share is to install energy piles when constructing a building, which is becoming an increasingly common practice. This case study focuses on such a system designed for a large, non-residential building in Zagreb, Croatia. The complex was designed as 13 separate dilatations, with central heating and cooling of all facilities, covered by 260 energy piles (130 pairs in serial connection), with a length of the polyethylene pipe of 20 m in a double loop inserted within the pile. The thermo-technical system was designed as a bivalent parallel system, with natural gas covering peak heating loads and a dry cooler covering cooling peak loads when the loads cannot be covered only by ground-source heat pumps. In the parallel bivalent system, the geothermal source will work with a much higher number of working hours at full load than is the case for geothermal systems that are dimensioned to peak consumption. Therefore, the thermal response test was conducted on two energy piles, connected in series, to obtain thermogeological parameters and determine the heat extraction and rejection rates. The established steady-state heat rate defines the long-term ability to extract heat energy during constant thermal load, with the inlet water temperature from the pile completely stabilized, i.e., no significant further sub-cooling is achieved in the function of the geothermal field operation time. Considering the heating and cooling loads of the building, modeling of the system was performed in such a manner that it utilized renewable energy as much as possible by finding a bivalent point where the geothermal system works efficiently. It was concluded that the optimal use of the geothermal field covers total heating needs and 70% for cooling, with dry coolers covering the remaining 30%. Additionally, based on the measured thermogeological parameters, simulations of the thermal response test were conducted to determine heat extraction and rejection rates for energy piles with various geometrical parameters of the heat exchanger pipe and fluid flow variations.