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A Multicenter, Randomized, Open-Labeled, Parallel Group Trial of Sildenafil in Alcohol-Associated Erectile Dysfunction: The Impact on Psychosocial Outcomes

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type , Journal 23 Sep 2009Publisher:MDPI AGJournal:International Journal of Environmental Research and Public Health, volume 6, pages 2,510-2,525 (eissn: 1660-4601,

Authors: Alexander M. Ponizovsky; Lev Averbuch; Alexander Grinshpoon; Ira Radomislensky;

doi: 10.3390/ijerph6092510

pmid: 19826560

pmc: PMC2760426

A Multicenter, Randomized, Open-Labeled, Parallel Group Trial of Sildenafil in Alcohol-Associated Erectile Dysfunction: The Impact on Psychosocial Outcomes

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Abstract

To examine the effect of sildenafil on erectile dysfunction (ED) and psychosocial outcomes in alcohol-dependent (AD) men, 108 men with these diagnoses were randomly assigned to either take sildenafil (50 mg) as add-on to standard treatment for AD, or the same treatment without sildenafil, for 12 weeks. Only 50 patients in sildenafil group and 51 in control group twice completed the International Index of Erectile Function (IIEF) and a battery of self-report questionnaires. IIEF scores and psychosocial functioning, self-esteem and support from friends improved only for sildenafil-treated patients (P < 0.001). The high effect sizes suggest that the observed benefits are unlikely to be a placebo effect, although their unspecific nature could not be ruled out. In men with ED associated with AD, sildenafil improves both ED and psychosocial outcomes. Further placebo-controlled clinical trial is warranted.

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Keywords

Adult, Male, Adolescent, Ethanol, Phosphodiesterase Inhibitors, Middle Aged, Article, Piperazines, Sildenafil Citrate, Young Adult, Treatment Outcome, alcohol dependence; erectile dysfunction; sildenafil; depression; functioning; self-esteem; social support, Erectile Dysfunction, Purines, Humans, Sulfones

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