The Vanj River Basin contains a dynamic glacier, the Medvezhiy glacier, which occasionally poses a danger to local residents due to its surging, flooding, and frequent blockages of the Abdukahor River, leading to intense glacial lake outburst floods (GLOF). This study offers a new perspective on the quantitative assessment of glacier surface velocities and associated lake changes during six surges from 1968 to 2023 by using time-series imagery (Corona, Hexagon, Landsat), SRTM elevation maps, ITS_LIVE, unmanned aerial vehicles, local climate, and glacier surface elevation changes. Six turbulent periods (1968, 1973, 1977, 1989–1990, 2001, and 2011) were investigated, each lasting three years within a 10–11-year cycle. During inactive phases, a reduction in the thickness of the glacier tongue in the ablation zone occurred. During a surge in 2011, the flow accelerated, creating an ice dam and conditions for GLOF. Using these datasets, we reconstructed the process of the Medvezhiy glacier surge with high detail and identified a clear signal of uplift in the surface above the lower glacier tongue as well as a uniform increase in velocities associated with the onset of the surge. The increased activity of the Medvezhiy glacier and seasonal fluctuations in surface runoff are closely linked to climatic factors throughout the surge phase, and recent UAV observations indicate the absence of GLOFs in the glacier’s channel. Comprehending the processes of glacier movements and related changes at a regional level is crucial for implementing more proactive measures and identifying appropriate strategies for mitigation.